桔梗皂苷D

分析标准品,HPLC≥98%

Platycodin D

CAS号：58479-68-8

分子式：C57H92O28

分子量：1225.34

MDL：MFCD09952590

产品介绍

熔点：228-237℃

外观：白色结晶性粉末

溶解性：难溶于水，易溶于甲醇、乙醇等有机溶剂和稀碱中。

敏感性：易吸潮

储存条件：2-8℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(27篇)

27. [IF=4.9] Lu Jiani et al."Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D."Natural Products and Bioprospecting.2025 Dec;15(1):1-22

26. [IF=5.4] Yuxia Wang et al."Improvement Effect of Shengxian Decoction on Cardiac Toxicity Induced by Arsenic Trioxide in Rats."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jun;:120163

25. [IF=3.2] Zhiying Feng et al."Exploration of the Active Components and Mechanism of Jiegeng (Platycodonis Radix) in the Treatment of Influenza Virus Pneumonia Through Network Pharmacology Analysis and Experimental Verification."Chemical Biology & Drug Design.2024 N

24. [IF=1.6] Shuncheng Zhao et al."Effects of electron beam irradiation on microbial load, physicochemical properties, sensory quality, stability of active components, and antioxidant activity of Platycodon grandiflorum (Jacq.) A. DC.."APPLIED RADIATION AND ISOTOPES.2

23. [IF=5.5] Liu Hui et al."Platycodin D facilitates antiviral immunity through inhibiting cytokine storm via targeting K63-linked TRAF6 ubiquitination."JOURNAL OF LEUKOCYTE BIOLOGY".2024 Mar;:

22. [IF=4.4] Pang Tao et al."Evaluating the Compatibility Mechanism of Shengxian Decoction Based on an Excretion Study of 18 Bioactive Constituents in Rat Biosamples."World Journal of Traditional Chinese Medicine".2024 Feb;10(1):40

21. [IF=4.3] Yu Hanwen et al."Identification and functional characterization of two trans-isopentenyl diphosphate synthases and one squalene synthase involved in triterpenoid biosynthesis in Platycodon grandiflorus."PLANTA.2023 Dec;258(6):1-13

20. [IF=1.8] Yan Liu et al."Effect of Developmental Stages on the Biosynthesis of Triterpene Saponins  and Related Gene Expression in  Seedlings of Platycodon grandiflorus."Natural Product Communications.10.1177/1934578X231191886

19. [IF=1.496] Xinying Du et al."Platycodin D-Induced Immunotoxicity in RAW 264.7 Macrophages via Oxidative Stress-Mediated Apoptosis."Natural Product Communications.

18. [IF=3.111] Zhen Ni et al."Platycodin D inhibits the proliferation, invasion and migration of endometrial cancer cells by blocking the PI3K/Akt signaling pathway via ADRA2A upregulation."Oncology Letters.2023 Apr;25(4):1-9

17. [IF=6.819] Chunjing  Guo et al."A novel saponin liposomes based on the couplet medicines of Platycodon grandiflorum–Glycyrrhiza uralensis for targeting lung cancer."DRUG DELIVERY

16. [IF=7.666] Shuyu Zheng et al."Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non–Small-Cell Lung Cancer."Cells.2022 Jan;11(15):2360

15. [IF=2.311] Xiaoyu Zhang et al."Effects of Platycodin D on apoptosis, migration, invasion and cell cycle arrest of gallbladder cancer cells."Oncol Lett. 2020 Dec;20(6):1-1

14. [IF=3.205] Chi Zhang et al."Components study on antitussive effect and holistic mechanism of Platycodonis Radix based on spectrum-effect relationship and metabonomics analysis."J Chromatogr B. 2021 May;1173:122680

13. [IF=3.935] Tong Xie et al."A post processing strategy to score and rank the annotation confidence of saponins in natural products by integrating MS2 spectral similarity and fragment interpretation."J Pharmaceut Biomed. 2021 Sep;204:114291

12. [IF=4.821] Xiangwei Chang et al."Untargeted metabolomics approach reveals the tissue-specific markers of balloon flower root (Platycodi Radix) using UPLC-Q-TOF/MS."Microchem J. 2021 Sep;168:106447

11. [IF=4.932] Ruiqi Guo et al."Anti-inflammatory effects of Platycodin D on dextran sulfate sodium (DSS) induced colitis and E. coli Lipopolysaccharide (LPS) induced inflammation."Int Immunopharmacol. 2021 May;94:107474

10. [IF=3.565] Ruolin Zhao et al."Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways."J Cancer. 2015; 6(7): 623–631

9.  Zhang, Chi, et al. "Components study on antitussive effect and holistic mechanism of Platycodonis Radix based on spectrum-effect relationship and metabonomics analysis." Journal of Chromatography B 1173 (2021): 122680.https:##doi.org/10.1016/j.jchromb.2021

8.  马琳琳,何慧,张世科,李威.桔梗皂苷-D诱导Hela细胞凋亡的作用及机制研究[J].现代中西医结合杂志,2020,29(22):2429-2436.

7.  王菊,李龙,曾家顺.桔梗皂苷D对MH7A细胞迁移和侵袭的影响及其机制的研究[J].贵州医药,2020,44(10):1515-1517+1681.

6.  王菊,李龙,曾家顺.桔梗皂苷D对MH7A细胞增殖和凋亡的影响及机制[J].贵州医科大学学报,2020,45(10):1149-1155.

5.  曾静凯 郭青.不同产地桔梗性状、浸出物、桔梗皂苷D含量及HPLC指纹图谱比较[J].中国实验方剂学杂志 2017 23(24):62-70.

4.  马琳琳, 何慧, 张世科,等. 桔梗皂苷-D诱导Hela细胞凋亡的作用及机制研究[J]. 现代中西医结合杂志 2020年29卷22期, 2429-2436页, ISTIC CA, 2020.

3.  赵若琳,周坤福,张旭,陈美娟.桔梗皂苷-D抑制非小细胞肺癌H460和A549细胞黏附、侵袭和迁移的作用机制研究[J].中国药理学通报,2015,31(02):241-247.

2.  朱立芬, 王冰. 桔梗皂苷D防御口腔黏膜上皮细胞感染白色念珠菌的作用[J]. 中国病理生理杂志, 2017(1):161-165.

1.  文宇萍, 金铁. 机筒温度与物料含水量对挤压桔梗的膨化特性及桔梗皂苷D含量的影响[J]. 延边大学农学学报, 2019, 041(003):83-88.